The lobby is an expansive space with an open ceiling and an eye-catching jumble of design elements, including a retro-style motorcycle and sidecar. Organic materials, such as rammed-earth walls, reference the desert landscape, while mirrored columns and iridescent mosaic tiles add vibrancy. The snake motif on the lobby carpet connects to the snakeskin-clad bar in the adjacent Bar Moxy. A mezzanine level is home to two Meeting Studios along with additional seating, including oversize lounge chairs; vintage arcade games, an armadillo-shaped LED neon sculpture, and a DJ booth add a playful energy. With reconfigurable furniture throughout, the lobby becomes the living, breathing heart of the hotel, a place for guests to use as a breakfast room, fueling station, or place to connect with friends old and new over a drink.

The 380 cozy bedrooms at Moxy Downtown LA are designed for flexibility and personalization, welcoming tourists and not with a thoughtful balance of utility and panache. Floor-to-ceiling windows allow the SoCal sunshine to pour in. Distressed leather headboards evoke a well-worn motorcycle jacket, and cryptic markings on the wall reference the "hobo hieroglyphics" used by history's vagabonds. Adaptable, space-saving furniture and storage solutions allow guests to stake their own claim to the space. Industrial-chic bathrooms, lined in iridescent copper tile, feature a rain shower and an elongated sink carved from lava stone. Hanging on one wall is a sculpture that consists of chrome motorcycle handlebars mounted on a taxidermy-style plaque, a clever amalgamation of the twin desert themes of bikers and wildlife.